Old Research direction, rejuvenated approach

Dr. Yakub Hanna from the Weizmann Institute of sciences has published a novel approach that could potentially circumvent the usual hindrance faced during stem cell reprogramming. He has published data that exhibits his work on a MBD3. Deletion of this gene from adult cells have proven to improve the efficiency of reprogramming by several orders of magnitude.
More on this (http://www.sciencedaily.com/releases/2013/09/130918132440.htm?goback=%2Egde_3904837_member_275221827#%21)



The nature publication
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12587.html

Deterministic direct reprogramming of somatic cells to pluripotency

• Yoach Rais,
• Asaf Zviran,
• Shay Geula,
• Ohad Gafni,
• Elad Chomsky,
• Sergey Viukov,
• Abed AlFatah Mansour,
• Inbal Caspi,
• Vladislav Krupalnik,
• Mirie Zerbib,
• Itay Maza,
• Nofar Mor,
• Dror Baran,
• Leehee Weinberger,
• Diego A. Jaitin,
• David Lara-Astiaso,
• Ronnie Blecher-Gonen,
• Zohar Shipony,
• Zohar Mukamel,
• Tzachi Hagai,
• Shlomit Gilad,
• Daniela Amann-Zalcenstein,
• Amos Tanay,
• Ido Amit,
• Noa Novershtern
• et al.

• Nature

   

  (2013)

   

  doi:10.1038/nature12587

  Received

   

  03 April 2013 

  Accepted

   

  23 August 2013 

  Published online

   

  18 September 2013

IPSCs from Urine epithelial cells

Came across this interesting paper, though published last year I think its pretty novel, and being published in nature its credibility is unquestionable, all I can say another step forward, kudos to the team!

Generation of human induced pluripotent stem cells from urine samples

• Ting Zhou,
• Christina Benda,
• Sarah Dunzinger,
• Yinghua Huang,
• Jenny Cy Ho,
• Jiayin Yang,
• Yu Wang,
• Ya Zhang,
• Qiang Zhuang,
• Yanhua Li,
• Xichen Bao,
• Hung-Fat Tse,
• Johannes Grillari,
• Regina Grillari-Voglauer,
• Duanqing Pei
• & Miguel A Esteban

• Nature Protocols

   

  7,

   

  2080–2089

   

  (2012)

   

  doi:10.1038/nprot.2012.115

  Published online

   

  08 November 2012

  http://www.nature.com/nprot/journal/v7/n12/abs/nprot.2012.115.html?WT.ec_id=NPROT-201212

Hybernation

Posting after almost 3 years, latest agenda is getting things back on track and continue to update non biologists and try and get them interested in this field. I cannot believe its been 3 years, but sometimes life has its own lessons to dole out.
Signing off